By: Ricky Hussey

Paget's disease is a chronic bone disorder that is due to irregular breakdown and formation of bone tissue. Paget's disease can cause bones to expand and weaken and may result in bone pain, arthritis, bone deformity and fractures. It is usually localized to one bone, but can involve many bones. Paget's disease is also known as osteitis deformans. Paget's disease can cause bones to expand and weaken and may result in bone pain, arthritis, bone deformity and fractures. Paget's disease is rarely effected people under 40. Men and women are approximately equally affected. The prevalence of Paget's disease ranges from 1.5 to 8% depending on age and country of residence. The prevalence of familial Paget's disease (where more than one family member has the disease) ranges from 10 to 40% in different parts of the world.

Causes of Paget's disease

The cause of Paget's disease is unknown, but certain women seem to be at a higher risk of developing breast cancer. This includes women who have never had children, or had them late in life, women who started their periods at a young age or who had a late menopause, and women who have a strong family history of breast cancer.

Symptoms

* Bone pain (may be severe and persistent) * Joint pain or joint stiffness * Headache * Bowing of the legs * Warmth of skin overlying affected bone

Paget's Disease Treatment

Paget's disease of the breast usually requires surgery. Which type of surgery you need depends on the condition of the skin around your nipple and how advanced the underlying cancer is.

Surgical options include:

* Simple mastectomy. This procedure involves removing your breast, but not the lymph nodes in your armpit (axillary lymph nodes). Simple mastectomy is recommended in cases in which an underlying breast cancer exists but it isn't invasive breast cancer and it hasn't spread to the lymph nodes.

Medicine

* Bisphosphonates (pronounced by-fahs-fe-nates) are often used to treat Paget’s disease. These are a type of medicine that can help the body to produce normal bone.

Prevention

You can't avoid certain risk factors for breast cancer, such as your age, genetics or family history. But other factors that could increase your chances of developing breast cancer are well within your control. Healthy lifestyle habits, such as getting enough exercise, limiting alcohol and eating right, may offer you some protection from breast cancer.

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